In these patients, a positive test can lead to `overdiagnosis’ and probably `overtreatment’. False-positive results have been reported for patients with rheumatoid arthritis, systemic lupus erythematosus, infectious mononucleosis, syphilis and other spirochaetal diseases .
Is there a connection between Lyme disease and lupus?
Post-Treatment Lyme Disease Syndrome and Autoimmune Diseases Additionally, some patients may develop autoimmune joint diseases, such as rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis, and other autoimmune diseases, including lupus, polymyalgia rheumatica, thyroid disease, and autoimmune neuropathy.
What causes false positive Lyme antibody?
Epstein-Barr virus infection is known to cause false-positive results in Lyme disease serologic testing, particularly IgM tests, and samples from patients with recent EBV infection are commonly part of the serum panel used to study antibody-based tests for Lyme disease [2, 3, 8, 9].
Can a positive Lyme test be wrong?
If you have been infected for longer than 4 to 6 weeks and the IgG Western Blot is still negative, it is highly likely that the IgM result is incorrect (e.g., a false positive). This does not mean that you are not ill, but it does suggest that the cause of illness is something other than the Lyme disease bacterium.
Can lupus cause false positive Lyme Related Questions
What diseases can cause false-positive Lyme test?
For example, even if you have had Lyme disease and been cured, antibodies may still be found months or years later. False-positive results can also happen if you have the autoimmune disease lupus, HIV, or syphilis. They can also happen if you have Helicobacter pylori bacteria or the Epstein-Barr virus.
What autoimmune disease can cause a false-positive for Lyme disease?
One of the most common Lyme disease misdiagnoses is the autoimmune disease rheumatoid arthritis (RA), characterized by chronic joint pain.
What is Lyme disease commonly misdiagnosed as?
Patients with Lyme disease have been incorrectly diagnosed with: multiple sclerosis (MS), fibromyalgia, chronic fatigue syndrome, autoimmune diseases including lupus and rheumatoid arthritis [1-7], polymyalgia rheumatica, thyroid disease, and psychiatric disorders, among others.
What diseases go along with lupus?
Autoimmune thyroid disease. Celiac disease. Myasthenia gravis. Antiphospholipid syndrome. Rheumatoid arthritis. Polymyositis. Dermatomyositis. Scleroderma.
What disease is confused with Lyme disease?
Chronic Lyme disease, for instance, has symptoms very similar to those of several other chronic illnesses, such as juvenile idiopathic arthritis, fibromyalgia, and myalgic encephalomyelitis/chronic fatigue syndrome. Multiple sclerosis and arthritis also have symptoms similar to Lyme disease.
Why did I test positive for Lyme disease?
A positive blood test result means that antibodies to fight the Lyme disease bacteria were found in your blood. In this case, the Centers for Disease Control and Prevention (CDC) recommends a second blood test on the same blood sample.
Why Lyme testing is inaccurate?
One reason is timing. It can take weeks or even longer for the body to create a detectable immune response. Unless and until the body develops these antibodies, the tests will be negative, even if the person has Lyme disease. Thus, when the timing of diagnosis is most critical, the two-tier test is least effective.
How often are Lyme tests wrong?
Lyme disease is known to inhibit the immune system and 20-30% of patients have falsely negative antibody tests.
What percentage of Lyme disease tests are false positive?
While these labs strive for high sensitivity they do not outperform reference labs in finding Lyme disease.  Moreover, specificity as low as 43% is reported, indicating that 57% of results coming from such labs are false positives.
Is Lyme disease the same as autoimmune disease?
How are Lyme Disease Autoimmune Disease Different? Autoimmune disease occurs when the body mistakenly attacks its own healthy cells. Lyme disease (Lyme borreliosis) is a systemic bacterial infection caused by Borrelia burgdorferi, the Lyme disease bacteria that is transmitted through a black-legged tick bite.
What is a unique symptom of Lyme disease?
Unusual symptoms of Lyme disease may include heart problems like arrhythmia and palpitations, neurological issues like tremors or numbness, and difficulty with memory and concentration.
What are 4 other signs of Lyme disease?
A red rash called erythema migrans (EM). Most people with Lyme disease get this rash. It gets bigger over several days and may feel warm. It is usually not painful or itchy. Fever. Chills. Headache. Fatigue. Muscle and joint aches. Swollen lymph nodes.
What is a more accurate Lyme disease test?
A blood test does not only detect Lyme disease; it is the most accurate and preferred test for diagnosing the disease. If a patient with Lyme disease shows signs that the central nervous system has been affected by the disease, western blot testing on the cerebrospinal fluid (CSF) can be performed.
What organ does lupus affect the most?
Kidneys About one half of people with lupus experience kidney involvement, and the kidney has become the most extensively studied organ affected by lupus.
What can trigger lupus?
Lupus can be triggered by certain types of blood pressure medications, anti-seizure medications and antibiotics. People who have drug-induced lupus usually get better when they stop taking the medication. Rarely, symptoms may persist even after the drug is stopped.
How did you know you had lupus?
Some of the most common signs of lupus are a rash and joint pain, says Konstantinos Loupasakis, MD, a rheumatologist with MedStar Washington Hospital Center, but symptoms can also include fatigue, hair loss, mouth sores, and fever. ‚ÄúThere’s a great range of manifestations we see with lupus,‚Äù he says.