Even if the patient develops IVIG-associated aseptic meningitis, IVIG therapy need not be withheld and should be continued at a slow infusion rate, with proper hydration, antihistamines and analgesics, as it is a life-saving drug for GBS.
Is aseptic meningitis related to IVIG?
Aseptic meningitis (AM) is considered an uncommon adverse reaction associated with the course of intravenous immunoglobulin therapy. It can be linked to 0.067% of all infusions with the incidence being higher following IVIG treatment in patients with Guillain-Barre syndrome .
How do you treat aseptic meningitis?
Antibiotics. Antivirals. Antifungals, Systemic. Antitubercular Agents. Corticosteroids. Anticonvulsants, Other. Acetaminophen (Aspirin-Free Anacin Extra Strength, FeverAll, Rapimed Junior, Tylenol)
What are the symptoms of IVIG induced aseptic meningitis?
Several studies have reported that aseptic meningitis appears within 48 h of the initiation of IVIG therapy (64, 66, 67). The most common presenting symptoms of this condition are persistent headache, nausea, vomiting, photophobia, fever, chills, and positive Kernig’s and Brudzinski’s signs.
How is IVIG induced aseptic meningitis treated Related Questions
How long does it take for aseptic meningitis to go away?
Aseptic (viral) meningitis is serious but rarely fatal in healthy people with normal immune systems. Usually, symptoms last from 7 to 10 days and the patient recovers completely. People with this condition may have the following symptoms: Headache.
Does drug induced aseptic meningitis go away?
Most meningeal signs and symptoms resolve within 24 to 48 hours of stopping the offending drug. In-hospital observation and treatment with IV antibiotics is appropriate until bacterial meningitis has been ruled out.
What medication is used for aseptic meningitis?
Biologic drugs such as intravenous immunoglobulin (IVIG). Monoclonal antibodies such as Infliximab, Adalimumab, Etanercept, Efalizumab, Cetuximab, and OKT3 antibodies. Chemotherapeutic drugs such as Pemetrexed and Cytarabine.
How do you know if you have aseptic meningitis?
Patients with aseptic meningitis often present with classic meningeal symptoms, including fever, neck pain or stiffness, photophobia, headache, nausea or vomiting and perhaps altered mental status although this is NOT a prominent feature of viral meningitis, the most common cause of aseptic meningitis.
What is the first line drug for aseptic meningitis?
Primary treatment is with either cefotaxime (50 mg/kg IV every 6 hours, up to 12 g/day) or ceftriaxone (75 mg/kg initially, then 50 mg/kg every 12 hours, up to 4 g/day).
What is the death rate of aseptic meningitis?
Symptoms of meningitis caused by an acute viral infection last between one and two weeks. When aseptic meningitis is caused by cytomegalovirus 20 percent of individuals face mortality or morbidity. If left untreated it can affect an individual’s hearing and learning abilities.
Is aseptic meningitis an emergency?
If you have any combination of symptoms suggestive of meningitis, seek urgent medical treatment. In particular, seek medical treatment if you have a fever along with a headache, neck stiffness, or confusion.
Can aseptic meningitis cause brain damage?
Aseptic meningitis is generally distressing, but it’s not usually dangerous. Most people experience complete recovery within a few weeks. However, this condition can lead to serious problems, including blood clots in the brain, encephalitis, systemic spread of the infection, and lasting brain damage.
What is a severe reaction to IVIG?
Immediate reaction to IVIG often observed. The most common adverse reactions include headache, nausea, myalgia, fever, and chills and often arise immediately during or after the infusion.
What are serious reactions to IVIG?
Very rarely, more serious side effects like allergic reactions or low blood counts (anemia) can occur. One of the most common side effects is headache. Other side effects include chills, fever, flushing, flu-like muscle pains or joint pains, feeling tired, having nausea, vomiting, and rash.
How long does it take for IVIG to get out of your system?
How long does IVIG stay in your system? The half-life of IVIG in the body is, on average, about 25 days. It usually takes roughly 4-5 half-lives to clear the majority of IVIG from your body.
What are the long term effects of aseptic meningitis?
recurrent seizures (epilepsy) problems with memory and concentration. co-ordination, movement and balance problems. learning difficulties and behavioural problems.
What is the progression of aseptic meningitis?
Progression of Aseptic Meningitis (Sterile Meningitis) However, tiredness, lightheadedness and muscle aches may persist for a period of time after recovery. Encephalitis (infection of brain itself) may develop rarely. Infection may last much longer in a person with a depressed immune system.
Does aseptic meningitis show on MRI?
Until this is made, aseptic meningitis and aseptic meningoencephalitis can recur. MRI is helpful in these cases, indicating brain involvement secondary to vasculitis and excluding lesions such as prominent meningeal enhancement, characteristic of bacterial meningitis.
What is aseptic meningitis mostly caused by?
Overall, viral infection is the most common form of aseptic meningitis, and enteroviruses are the most common viral cause. Enteroviruses are small, nonenveloped RNA viruses of the picornavirus family with various serotypes.
Can coronavirus cause aseptic meningitis?
Infection with various picornaviruses may be asymptomatic or may cause clinical syndromes such as aseptic meningitis (the most common acute viral disease of the CNS), encephalitis, the common cold, febrile rash illnesses (hand-foot-and-mouth disease), conjunctivitis, herpangina, myositis and myocarditis, and hepatitis.