Lenalidomide-induced diarrhea in patients with myeloma is caused by bile acid malabsorption that responds to treatment | Blood | American Society of Hematology.
Does multiple myeloma affect bowels?
Gastrointestinal (GI) tract involvement in MM is rare and may represent a diagnostic challenge. The most commonly reported sites in the GI tract are the small intestine, stomach, and colon. Reported cases of GI manifestations include GI bleeding, abdominal pain, diarrhea, or bowel obstruction.
Does multiple myeloma cause upset stomach?
Novel therapies used to treat multiple myeloma may be associated with gastrointestinal problems (e.g., nausea, vomiting, diarrhea, and constipation). Do not stop or adjust medications without discussing it with your healthcare provider.
What are the signs that multiple myeloma is progressing?
As active multiple myeloma gets worse, you’ll likely feel sicker, with fatigue or bone pain. You may have anemia, bleeding problems, or a lot of infections. Other symptoms of advanced multiple myeloma include unusual fractures, shortness of breath, weakness, feeling very thirsty, and belly pain.
Why does multiple myeloma cause diarrhea Related Questions
How do you treat diarrhea in myeloma patients?
Loperamide, over-the-counter glutamine, octreotide (Somatostatin®), and budesonide (Entocort®) are four commonly cited drugs used to control chemotherapy-induced diarrhea.
Which cancers cause diarrhoea?
Certain cancers can cause diarrhea. These include neuroendocrine tumors, colon cancer, lymphoma, medullary thyroid cancer and pancreatic cancer.
What organ is most affected by multiple myeloma?
Multiple myeloma affects the plasma cells (a type of blood cell) inside the bone marrow. Myeloma does not usually take the form of a lump or tumour. Instead, the myeloma cells divide and expand within the bone marrow, damaging the bones and affecting the production of healthy blood cells.
Can myeloma spread to bowel?
Involvement of GI tract is seen in less than 10% of cases, frequent in the small intestinal tract, followed by the stomach colon and esophagus. Involvement of the GI tract in MM occurs later in disease progression or relapsing disease. Bleeding is more common in advanced stages of MM and likely an end-stage event.
What are the common problems with multiple myeloma?
a persistent bone pain, usually in the back, ribs or hips. tiredness, weakness and shortness of breath – caused by anaemia. high levels of calcium in the blood (hypercalcaemia) – which may cause symptoms including extreme thirst, stomach pain, needing to pee frequently, constipation or confusion.
What hurts when you have multiple myeloma?
Multiple myeloma can cause pain in affected bones – usually the back, ribs or hips. The pain is frequently a persistent dull ache, which may be made worse by movement.
What is the most common presenting symptom of multiple myeloma?
Bone pain is the most common presenting symptom in MM. Most case series report that 70% of patients have bone pain at presentation. The lumbar spine is one of the most common sites of pain. Pathologic fractures are very common in MM; 93% of patients have more than one site of bony involvement.
Does sugar feed multiple myeloma?
There are two crucial points to consider: first, the sugar pathways in the myeloma cells are not directly linked to the sugars that you eat. Second, any sugar you eat is immediately countered by insulin, which regulates, along with many other hormones, the uptake and use of sugar throughout your body.
How quickly can multiple myeloma spread?
How quickly multiple myeloma progresses can vary between people. An older 2007 study of 276 people found that there was a 10% risk of progression in people with early multiple myeloma per year for the first 5 years of illness.
Is multiple myeloma hard to cure?
While there is no cure for multiple myeloma, the cancer can be managed successfully in many patients for years. The common types of treatments used for multiple myeloma are described below. Your care plan may also include treatment for symptoms and side effects, an important part of cancer care.
Can multiple myeloma get better?
Treatment for multiple myeloma can often help control symptoms and improve quality of life. But myeloma usually can’t be cured, which means additional treatment is needed when the cancer comes back.
What to do if a patient has diarrhea?
The most important treatment for diarrhea is to drink fluids that contain water, salt, and sugar, such as oral rehydration solution (ORS). Sports drinks (eg, Gatorade) may be acceptable if you are not dehydrated and are otherwise healthy.
How much water should myeloma patient drink?
Drink plenty of fluids to keep your kidneys working properly. Try to drink about 3 litres (5 pints) of fluids (ideally water) each day. Also, avoid alcohol or cut down. If you do take an alcoholic drink, drink extra fluids on that day.
How do you stop mass diarrhea?
A good rule of thumb is to drink at least 1 cup of liquid every time you have a loose bowel movement. Water, Pedialyte, fruit juices, caffeine-free soda, and salty broths are some good choices. According to the Cleveland Clinic, salt helps slow down the fluid loss, and sugar will help your body absorb the salt.
Why do I get watery diarrhea?
The most common cause of diarrhea is the stomach flu (viral gastroenteritis). This mild viral infection most often goes away on its own within a few days. Eating or drinking food or water that contains certain types of bacteria or parasites can also lead to diarrhea. This problem may be called food poisoning.
What is causing me to have diarrhea all the time?
Some infections, food allergies and intolerances, digestive tract problems, abdominal surgery, and long-term use of medicines can cause chronic diarrhea. Some infections from bacteria and parasites that cause diarrhea do not go away quickly without treatment.