What causes low glucose in CSF?

So, you want to know What causes low glucose in CSF?

Hypoglycorrhachia, a low glucose level in the cerebrospinal fluid (CSF), is commonly associated with infections such as bacterial, fungal, and tuberculous meningitis 1. When tests for these infectious causes are negative, the diagnosis can be elusive.

What is the CSF glucose of patient with bacterial meningitis?

In bacterial meningitis, the CSF glucose level (reference range, 40-70 mg/dL) is less than 40 mg/dL in 60% of patients. A simultaneous blood glucose determination should be obtained for the purposes of comparison.

Is glucose increased or decreased in bacterial meningitis?

Meningitis can be caused by bacterial, fungal or viral pathogens. One hallmark of bacterial meningitis is reduced glucose levels in the cerebrospinal fluid (CSF) of patients, which allows a physician to quickly begin appropriate antibiotic treatment.

Which virus causes low CSF glucose?

A low CSF glucose is rare in viral CNS infections, but moderate hypoglycorrhachia may occur in viral CNS infections due to mumps virus, enterovirus, and herpes simplex virus 1.

What causes low glucose in CSF Related Questions

When is glucose level low in CSF?

Normal levels of glucose in the CSF are greater than 50 mg/dL to 75 mg/dL. If your levels are lower, you may have an infection. Your healthcare provider will look at your CSF glucose level along with the other CSF tests, and possibly other tests, to better understand what your results mean.

Why is glucose increased in CSF meningitis?

High CSF glucose levels In addition, damage to small blood vessels during lumbar puncture (traumatic tap) can lead to an increased CSF glucose since the blood that enters the collected CSF sample contains higher levels of glucose.

What happens to CSF in bacterial meningitis?

Typically in CSF, levels of protein increase, and because bacteria consume glucose and because less glucose is transported into the CSF, glucose levels decrease. Brain parenchyma is typically affected in acute bacterial meningitis.

What are typical CSF findings in bacterial meningitis?

Cell Count Normal CSF may contain up to 5 WBCs per mm3 in adults and 20 WBCs per mm3 in newborns. Eighty-seven percent of patients with bacterial meningitis will have a WBC count higher than 1,000 per mm,3 while 99 percent will have more than 100 per mm3.

What is a positive CSF for bacterial meningitis?

Characteristic findings in bacterial meningitis include a CSF glucose concentration <40 mg/dL, a CSF to serum glucose ratio of ≤0.4, a protein concentration >200 mg/dL, and a white blood cell (WBC) count above 1000/microL, usually composed primarily of neutrophils [2,8,12].

What is the glucose and protein level in CSF in bacterial meningitis?

CSF glucose Whilst not diagnostic, low glucose levels, as compared to plasma levels, are seen in bacterial meningitis, cryptococcal meningitis, malignant involvement of the meninges and sarcoidosis. Glucose levels are usually normal in viral infections of the CNS.

What is the relationship between glucose and protein in bacterial or viral meningitis?

The clues that the doctor uses are the levels of white cells, protein and glucose in the CSF. Typically in bacterial meningitis the white cell count is much higher than in viral meningitis (and is a different type of white cell), the protein is much higher and the glucose is much lower than in viral meningitis.

How can you tell the difference between viral and bacterial meningitis?

Nausea. Vomiting. Fever. Severe headache. Stiff neck. Irritability. Discomfort looking into bright light. Confusion.

What is associated with low CSF glucose and high protein?

High CSF protein and low CSF glucose have been associated with increased risk of sensorineural hearing loss in bacterial meningitis [5, 6].

What is a CSF analysis for meningitis?

A CSF analysis is used to measure different substances in your cerebrospinal fluid. It may include tests to diagnose: Infectious diseases of the brain and spinal cord, including meningitis and encephalitis. CSF tests for infections look at white blood cells, bacteria, and other substances in the cerebrospinal fluid.

What does CSF glucose indicate?

A CSF glucose test measures the amount of sugar (glucose) in the cerebrospinal fluid (CSF). CSF is a clear fluid that flows in the space surrounding the spinal cord and brain. A lumbar puncture, or spinal tap, is a procedure to collect cerebrospinal fluid to check for the presence of disease or injury.

Why did the CSF show a low level of glucose and a high level of protein?

An abnormal protein level in the CSF suggests a problem in the central nervous system. Increased protein level may be a sign of a tumor, bleeding, nerve inflammation, or injury. A blockage in the flow of spinal fluid can cause the rapid buildup of protein in the lower spinal area.

Which CSF component will decrease in bacterial meningitis?

The CSF glucose concentration is usually reduced in bacterial meningitis. A normal CSF glucose level should be higher than two thirds of the serum glucose level; a CSF level lower than 50% of the serum level is suggestive of bacterial meningitis.

What is the pathophysiological change in bacterial meningitis?

The pathogenesis and pathophysiology of bacterial meningitis involve a complex interplay between virulence factors of the pathogens and the host immune response [3,4]. Much of the damage from this infection is believed to result from cytokines released within the CSF as the host mounts an inflammatory response.

What is the pathophysiological mechanism behind bacterial meningitis?

Bacterial meningitis is characterized by the entry of bacteria into the cerebrospinal fluid (CSF) and bacterial growth in this compartment leading to inflammation within the CSF and the adjacent brain tissue.

What are three parameters which indicates bacterial meningitis when testing a CSF?

A number of indicators such as hypersensitive C-reactive protein (hsCRP), lactate dehydrogenase (LDH), white blood cell count (WBCs), and glucose level in CSF have been proved to be valuable in the diagnosis of bacterial meningitis.

Leave a Comment